Porphyromonas gingivalis-감염 구강편평세포암종 세포에서의 mRNA 발현 변화
mRNA Expression in Porphyromonas Gingivalis-Infected Oral Squamous Cell Carcinoma Cells
박지은, 우복희, 박대근, 박봉수, 이지혜, 박혜련,
소속 상세정보
박지은 ( Park Ji-Eun ) - 부산대학교 치의학전문대학원 구강병리학교실
우복희 ( Woo Vok-Hee ) - 부산대학교 치의학전문대학원 구강병리학교실
박대근 ( Park Dae-Geun ) - 부산대학교 치의학전문대학원 구경병리학교실
박봉수 ( Park Bong-Soo ) - 부산대학교 치의학전문대학원 구강해부학교실
이지혜 ( Lee Ji-Hye ) - 부산대학교 치의학전문대학원 구경병리학교실
박혜련 ( Pak Hae-Ryoun ) - 부산대학교 치의학전문대학원 구강병리학교실
KMID : 0829220130370060311
Abstract
Chronic inflammation is widely considered to predispose individuals to cancer. Microorganisms facilitate recruitment and activation of inflammatory cells and thus allow release of inflammatory mediators. These molecules can then promote accumulation of mutations, leading to tumor development in the host. Porphyromonas gingivalis, a pathogen causing chronic periodontitis, is detected in oral squamous cell carcinoma (OSCC) tissues. Considering a strong link between chronic inflammation and tumor development, functional consequences of P. gingivalis infection may include malignant transformation of the host cells. In this study, we monitored transcriptional changes induced by invasion of P. gingivalis in OSCC cells using microarrays. Our preliminary results suggest changes in a wide range of genes involved in inflammation, apoptosis and autophagy, tumor progression, and carcinogenesis. Further studies on molecular mechanisms underlying these changes will lay a useful foundation to elucidate the role of microorganism-related inflammation and for the development of preventive and therapeutic agents for oral cancer.
키워드
Porphyromonas gingivalis; Squamous cell carcinoma; mRNA; Microarray
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